Transition from high cardiac output to elevated vascular resistance in hypertension

Transition from high cardiac output to elevated vascular resistance in hypertension.

The early phase of hypertension (borderline hypertension) is characterized by a hyperkinetic circulation caused by excessive sympathetic drive and decreased parasympathetic inhibition to the heart. In later phases the cardiac output becomes normal, but the hypertension is still neurogenic, as demonstrated by the fact that continued pharmacologic parasympathetic, beta- and alpha-adrenergic inhib...

Cardiac Output, and Vascular Resistance in Cardiac Transplant Recipients

Background An attenuated or absent nocturnal decline in blood pressure has repeatedly been documented in cardiac transplant recipients. The present study was aimed at investigating the hemodynamic mechanism underlying this abnormality. Methods and Results In 23 cardiac transplant recipients (11 to 36 months after transplantation) and in 23 control subjects matched for age and 24-hour mean arter...

Normal and High Cardiac Output Borderline Hypertension

30. Spann JR Jr, Mason DT, Zelis RF: The altered performance of the hypertrophied and failing heart. Am J Med Sci 258: 291, 1969 31. Mehmel HC, Mazzoni S, Krayenbuehl HP: Contractility of the hypertrophied human left ventricle in chronic pressure and volume overload. Am Heart J 90: 236, 1975 32. Williams JF Jr, Potter RD: Normal contractile state of hypertrophied myocardium after pulmonary arte...

Elevated vascular resistance and afterload reduce the cardiac output response to dobutamine in early growth-restricted rats in adulthood.

Epidemiological studies have linked intra-uterine growth restriction (IUGR) with an increased risk of CVD later in life. The aim of the present study was to examine the effect of maternal protein restriction on cardiac function in adulthood during dobutamine (DOB) stimulation. IUGR was induced in Wistar Kyoto dams through administration of a low-protein diet (LPD; 8.7 % casein) during pregnancy...

Relationship between cardiac output and peripheral resistance in borderline hypertension.